Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Benztropine
An antagonist of muscarinic M1 and M3 receptors that induces robust differentiation of oligodendrocytes precursor cell differentiation (EC50 = 500nM) and promotes myelination.
MilliporeSigma™ Calbiochem™ GSK-3β Peptide Inhibitor, Cell-permeable
The GSK-3β Peptide Inhibitor, Cell-permeable controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ IRE1 Inhibitor II
The IRE1 Inhibitor II controls the biological activity of IRE1.
MilliporeSigma™ Calbiochem™ PAR-2 Agonist I
The PAR-2 Agonist I controls the biological activity of PAR-2. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
MilliporeSigma™ Calbiochem™ MDM2 Inhibitor VII, MEL23
The MDM2 Inhibitor VII controls the biological activity of MDM2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ Ketohexokinase Inhibitor
An orally bioavailable pyrimidinopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of human hepatic KHK activity (KHK-C isoform; IC50 = 12nM in a transcreener ADP assay) and efficiently blocks fructose-1-phosphate secretion (IC50 ≤ 400nM in HepG2
MilliporeSigma™ Calbiochem™ (-)-Cytisine
A potent agonist selective for neuronal nAChRs (Ki = 2, 5890, 480, 329, and 492nM at α4β2, α7, α3β4, α6/α4β4, α1β1γδ, respective
MilliporeSigma™ Calbiochem™ Ginkgolic Acid (15:1)
A cell-permeable anacardic acid analog that inhibits protein SUMO .
MilliporeSigma™ Calbiochem™ CNQX
A potent and competitive antagonist for AMPA/kainate receptors (Ki
MilliporeSigma™ Calbiochem™ Chelerythrine Chloride
Naturally-occurring alkaloid.
MilliporeSigma™ Calbiochem™ Caspase Inhibitor VI
Z-VAD-FMK, CAS 161401-82-7, is an irreversible pan caspase inhibitor. Does not require pretreatment with esterase for in vitro studies.
MilliporeSigma™ Calbiochem™ Apoptosis Inhibitor II, NS3694
The Apoptosis Inhibitor II, NS3694, also referenced under CAS 426834-38-0, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ AG 825
A potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER2 (neu/ErbB2; IC50 = 0.35 μM) relative to HER1 (IC50 19 μM) autophosphorylation.
MilliporeSigma™ Calbiochem™ Tankyrase 1/2 Inhibitor VI, G007-LK
Tankyrase 1/2 Inhibitor VI, G007-LK, CAS 1380672-07-0, is a cell-permeable, potent and highly selective inhibitor of tankyrase (IC50 = 33 and 26nM for TNKS1 and TNKS2, respectively).
MilliporeSigma™ Calbiochem™ Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2, CAS 612847-09-3, is a cell-permeable, reversible inhibitor of Akt1/Akt2 (IC50 = 58 nM, 210 nM, & 2.12 μM for Akt1, Akt2, and Akt3, respectively).