Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Nifuroxazide
A cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity.
MilliporeSigma™ Calbiochem™ Mitochondrial Division Inhibitor, mdivi-1
The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp1.
MilliporeSigma™ Calbiochem™ Nicotinamide Phosphoribosyltransferase Inhibitor, FK866
The Nicotinamide Phosphoribosyltransferase Inhibitor, FK866, also referenced under CAS 658084-64-1, controls the biological activity of Nicotinamide Phosphoribosyltransferase. This small molecule/inhibitor is primarily used for Neuroscience applications.
MilliporeSigma™ Calbiochem™ SIRT2 Inhibitor, AGK2
The SIRT2 Inhibitor, AGK2, also referenced under CAS 304896-28-4, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications.
MilliporeSigma™ Calbiochem™ CXCR4 Antagonist IV, TF14016
A 14-aa internally disulfide-bonded peptide that potently competes against SDF-1α/CXCL12 for CXCR4 binding (IC50
MilliporeSigma™ Calbiochem™ Rosiglitazone
A thiazolidinedione compound that acts as an anti-diabetic agent and serves as a potent and selective agonist of peroxisome proliferator-activated receptor-γ (PPARγ) (Kd ∽40 nM) in fat cells.
MilliporeSigma™ Calbiochem™ T0901317
A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC50 of 20nM for LXRα
MilliporeSigma™ Calbiochem™ Telomerase Inhibitor IX
The Telomerase Inhibitor IX, also referenced under CAS 368449-04-1, controls the biological activity of Telomerase. This small molecule/inhibitor is primarily used for Cell Structure applications.
MilliporeSigma™ Calbiochem™ Sirt1 Inhibitor VII, Inauhzin
The Sirt1 Inhibitor VII, Inauhzin controls the biological activity of Sirt1. This small molecule/inhibitor is primarily used for Cell Structure applications.
MilliporeSigma™ Calbiochem™ Stauprimide
A cell-permeable ESCs (Embryonic Stem Cells) EMT (Epithelial-Mesenchymal Transition) inducer that is reported to prime/sensitize human and murine ESC cultures for much more enhanced/efficient differentiation into progenitor cells of multiple lineages.
MilliporeSigma™ Calbiochem™ InSolution™ β-Secretase Inhibitor IV
The InSolution™ β-Secretase Inhibitor, also referenced under CAS 797035-11-1, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
MilliporeSigma™ Calbiochem™ Stearoyl-CoA Desaturase 1 Inhibitor, MF-438
Stearoyl-CoA Desaturase 1 Inhibitor, MF-438, CAS 921605-87-0, is a cell-permeable inhibitor of Stearoyl-CoA Desaturase 1 (SCD1; IC50 of 2.3nM).
MilliporeSigma™ Calbiochem™ Smad3 Inhibitor, SIS3
Smad3 Inhibitor, SIS3, CAS 1009104-85-1, is a cell-permeable, selective inhibitor of TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated signaling. Does not affect Smad2, MAPK, ERK, or PI3-K.
MilliporeSigma™ Calbiochem™ TAPI-0
TAPI-0, CAS 143457-40-3, is a hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-α converting enzyme/ADAM17; IC50 = 100 nM).
MilliporeSigma™ Calbiochem™ Suramin, Sodium Salt
A reversible and competitive inhibitor of protein tyrosine phosphatases.